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Home > 학회활동 > 국제학술지 |
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작성일 : 10-10-29 16:35
| 저 자 |
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Rahyeong Juh et al |
| 제 목 |
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Quantification analysis of 123I-IPT single photon emission computed tomography uptake in the striatum of parkinsonism with the standard magnetic resonance template |
| 학회지명 |
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Psychiatry and Clinical Neurosciences |
| 권 호 |
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60 |
| 페이지 |
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18-28 |
| 년,월 |
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2006-10-29 |
| 링 크 |
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| Abstract |
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This study evaluated the striatal specific binding ratio (SBR), the anterior to posterior ratio of the
striatum (APR) and its reproducibility by employing a template-based registration (TBR) method
using the coregistered to the standard T1 magnetic resonance (MR) template (SMRT) as a replacement
for the MR image of each patient. The
123
I-IPT single photon emission computed tomography
(SPECT) images of 30 patients with Idiopathic Parkinson’s disease (IPD) and 11 normal controls
were analyzed. The region of interest (ROI) was positioned manually in the same slice showing the
highest striatal activity using the manual ROI method, while the ROI were positioned automatically
in the mid striatal slice of the SPECT image coregistered to the SMRT. The SBR obtained
using the TBR method showed a strong correlation with those using the manual method in all
groups: normal controls (
r
=
0.851,
P
=
0.001), early IPD (
r
=
0.841,
P
<
0.001), and severe IPD (
r
=
0.702,
P
=
0.007). The APR obtained by the TBR correlated with those using the manual method
in only the early IPD (
r
=
0.72,
P
=
0.001), while those obtained using the manual method showed
no correlation in the three groups (
P
>
0.05). The reproducibility (rmsCV) of the TBR method was
7.2% (normal controls, 5.2%; mild IPD, 4.2%; severe IPD, 10.8%), while the reproducibility of the
manual method was 31% (normal controls, 19.7%; mild IPD, 21.7%; severe IPD, 46.2%). This
shows that the use of
123
I-IPT SPECT for assessing IPD is affected by the method used to position
the striatal ROI. This study showed that the TBR method using the SMRT is useful in diagnosing
the IPD and assessing the disease severity with a high reproducibility, indicating a possibility of
using the TBR method as a good replacement for the manual method. |
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