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Home > 학회활동 > 국제학술지 |
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작성일 : 10-12-20 19:55
| 저 자 |
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Sang-Young Kim et al |
| 제 목 |
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Reversal of myo-inositol metabolic level in the left dorsolateral prefrontal cortex of rats exposed to a forced swimming test following desipramine treatment: an in vivo localized 1H-MRS study at 4.7 Tesla |
| 학회지명 |
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Magnetic Resonance Imaging |
| 권 호 |
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28 |
| 페이지 |
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1461-1467 |
| 년,월 |
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2010-5-1 |
| 링 크 |
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| Abstract |
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The forced swim test (FST) is a behavioral paradigm that is predicative of antidepressant activity in rodents. The objective of this study was to examine the effects of desipramine (DMI) pretreatment on behavioral and regional neurochemical responses in the left dorsolateral prefrontal cortex (DLPFC) and hippocampus of mice exposed to the FST using proton magnetic resonance spectroscopy (1H-MRS). An ultra short echo stimulated echo acquisition (STEAM) localization sequence (TR/TM/TE = 5000/20/2.2 ms) was used to measure in vivo proton spectra from the left DLPFC (voxel volume: 7 μl) and hippocampus (6 μl) of C57BL/6 mice at 9.4 T and acquired proton spectra post-processed offline with LCModel. The FST induced significant increase of glutamate (Glu) and myo-inositol (mIns) concentrations in the left DLPFC and hippocampus, respectively. In addition, creatine + phosphocreatine (Cr + PCr) concentrations in the left DLPFC were significantly decreased as compared to control. The metabolic alterations induced by the FST were reverted to level similar to control by acute DMI administration. Our results suggest that glutamatergic activity and glial cell dysfunction may contribute to the pathophysiological mechanisms underlying depression and that modulation of synaptic neurotransmitter concentrations represents a potential target for antidepressant drug development. |
 2010_김상영_MRI.pdf (948.5K) [860] DATE : 2011-10-11 13:35:51 |
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